Key Insights
The Asia-Pacific anticoccidial drugs market, valued at $390.12 million in 2025, is projected to experience robust growth, driven by a compound annual growth rate (CAGR) of 4.89% from 2025 to 2033. This expansion is fueled by several key factors. The increasing prevalence of coccidiosis in livestock, particularly poultry and swine, across the region necessitates the widespread use of anticoccidial drugs to maintain animal health and productivity. Rising demand for animal protein, coupled with intensification of livestock farming practices, further contributes to market growth. Furthermore, advancements in drug formulations, including the development of novel drug classes with improved efficacy and reduced side effects, are stimulating market expansion. The diverse segments within the market, encompassing various animal types (livestock and companion animals), distribution channels (veterinary hospitals, retail pharmacies, and others), drug classes (ionophores, antibiotics, sulphonamides, and others), and drug actions (coccidiostatic and coccidiocidal), provide opportunities for specialized product development and targeted marketing strategies. Competitive activity among leading players such as Ceva Animal Health, Elanco, Boehringer Ingelheim, Novartis, Zoetis, and others, further drives innovation and market penetration.
However, the market faces certain challenges. Stricter regulatory frameworks concerning the use of antibiotics in animal feed and growing consumer awareness regarding antibiotic resistance pose constraints to market growth. The fluctuating prices of raw materials and the potential for the emergence of drug-resistant coccidia strains also present risks. Nevertheless, the overall outlook for the Asia-Pacific anticoccidial drugs market remains positive, driven by the continuous need for effective disease control in livestock production and the ongoing efforts to develop safer and more effective anticoccidial drugs. The market's segmentation offers opportunities for companies to focus on niche areas and develop tailored solutions, ensuring sustained growth in the long term.

Asia-Pacific Anticoccidial Drugs Industry Market Report: 2019-2033
This comprehensive report provides a detailed analysis of the Asia-Pacific Anticoccidial Drugs market, offering invaluable insights for industry professionals, investors, and strategic decision-makers. Covering the period from 2019 to 2033 (Study Period), with a base year of 2025 and a forecast period of 2025-2033, this report delves into market dynamics, growth trends, key players, and future opportunities. The report segments the market by animal type (Livestock Animals, Companion Animals), distribution channel (Veterinary Hospitals, Retail Pharmacy, Other Distribution Channels), drug class (Ionophore, Antibiotic, Sulphonamides, Chemical Derivative, Other Drug Classes), and drug action (Coccidiostatic, Coccidiocidal). Market values are presented in Million units.
Asia-Pacific Anticoccidial Drugs Industry Market Dynamics & Structure
The Asia-Pacific Anticoccidial Drugs market is characterized by moderate concentration, with key players like Zoetis Animal Healthcare, Elanco, and Boehringer Ingelheim International GmbH holding significant market share. Technological innovation, driven by the need for improved efficacy and reduced side effects, is a key driver. Stringent regulatory frameworks, varying across countries, influence product approvals and market access. The market faces competition from alternative disease management strategies, including vaccination and improved hygiene practices. The demographic shift towards increased livestock production and pet ownership fuels market growth. Consolidation through M&A activities, as evidenced by recent deals like Ceva's joint venture in Japan (2022) and Elanco's product launch in Sri Lanka (2021), is reshaping the competitive landscape.
- Market Concentration: Moderately concentrated, with top 5 players holding xx% market share in 2024.
- Technological Innovation: Focus on novel drug delivery systems and improved efficacy.
- Regulatory Landscape: Varies significantly across the region, impacting market entry and product approvals.
- Competitive Substitutes: Vaccination programs and improved animal husbandry practices pose competition.
- M&A Activity: xx major deals observed between 2019-2024, indicating consolidation trends.
Asia-Pacific Anticoccidial Drugs Industry Growth Trends & Insights
The Asia-Pacific Anticoccidial Drugs market experienced robust growth during the historical period (2019-2024), driven by rising livestock populations, increasing awareness of coccidiosis, and expanding veterinary services. The market size reached xx million units in 2024 and is projected to witness a CAGR of xx% during the forecast period (2025-2033), reaching xx million units by 2033. Technological advancements, such as the development of more effective and safer drugs, contribute significantly to market expansion. Growing consumer preference for high-quality animal protein and improved animal welfare standards also influences demand. Adoption rates are relatively high in developed economies, while growth in developing economies is spurred by increasing livestock farming.

Dominant Regions, Countries, or Segments in Asia-Pacific Anticoccidial Drugs Industry
China and India dominate the Asia-Pacific Anticoccidial Drugs market, driven by their large livestock populations and expanding poultry industry. Within the animal segments, Livestock Animals, particularly poultry, accounts for the largest share, followed by other livestock. Veterinary hospitals are the dominant distribution channel, reflecting increasing veterinary care penetration. Ionophores constitute a major segment within drug classes, owing to their established efficacy and widespread use. Coccidiostatics dominate within drug action categories.
- Key Drivers: Rapid growth in livestock farming, particularly poultry, in China and India. Increased awareness of coccidiosis among farmers. Expansion of veterinary services.
- Dominant Segments: Livestock Animals (Poultry), Veterinary Hospitals, Ionophore Drug Class, Coccidiostatic Drug Action.
Asia-Pacific Anticoccidial Drugs Industry Product Landscape
The Anticoccidial drugs market features a range of products varying in drug class, administration route, and target species. Innovation focuses on enhancing efficacy, broadening the spectrum of activity, and minimizing side effects. Products are differentiated based on factors like dosage form, bioavailability, and cost-effectiveness. Technological advancements include the development of novel formulations that improve drug delivery and reduce environmental impact.
Key Drivers, Barriers & Challenges in Asia-Pacific Anticoccidial Drugs Industry
Key Drivers: Growing livestock populations, particularly poultry; rising awareness of coccidiosis; increased veterinary care penetration. Government initiatives promoting animal health and food safety.
Challenges: Stringent regulatory approval processes; high research and development costs; competition from generic drugs; potential for drug resistance; supply chain disruptions; fluctuating raw material prices impacting production costs. These challenges contribute to xx% reduction in profitability for some smaller players in the market.
Emerging Opportunities in Asia-Pacific Anticoccidial Drugs Industry
Untapped markets in Southeast Asia present significant growth potential. The increasing demand for sustainable and eco-friendly Anticoccidial drugs offers opportunities for innovative product development. The rising adoption of precision livestock farming technologies, alongside advancements in disease diagnostics, creates opportunities for integrated solutions combining drugs with preventative measures.
Growth Accelerators in the Asia-Pacific Anticoccidial Drugs Industry Industry
Strategic partnerships and collaborations between pharmaceutical companies and livestock producers can accelerate market penetration. Investments in research and development focusing on novel drug candidates and formulations are crucial. Expanding market access through improved distribution networks and targeted marketing strategies are key to future growth.
Key Players Shaping the Asia-Pacific Anticoccidial Drugs Market
- Ceva Animal Health Inc
- Elanco
- Boehringer Ingelheim International GmbH
- Novartis AG
- Zoetis Animal Healthcare
- Vetoquinol SA
- Impextraco NV
- MSD Animal Health
- Huvepharma
- Virbac
- Huvepharma
Notable Milestones in Asia-Pacific Anticoccidial Drugs Industry Sector
- April 2022: Ceva Santé Animale forms a joint venture with Mitsui & Co., Ltd. in Japan to expand its veterinary laboratory.
- March 2021: Elanco Animal Health launches two new veterinary products, including an Anticoccidial feed additive, in Sri Lanka through Baur & Co. Ltd.
In-Depth Asia-Pacific Anticoccidial Drugs Industry Market Outlook
The Asia-Pacific Anticoccidial Drugs market is poised for continued growth, driven by sustained demand for animal protein, technological advancements, and increasing investments in animal health infrastructure. Strategic opportunities lie in developing innovative products, expanding into untapped markets, and fostering collaborations to enhance market penetration and address emerging challenges. The market's future trajectory is positive, with significant potential for growth and innovation in the coming decade.
Asia-Pacific Anticoccidial Drugs Industry Segmentation
-
1. Drug Class
- 1.1. Ionophore
- 1.2. Antibiotic
- 1.3. Sulphonamides
- 1.4. Chemical Derivative
- 1.5. Other Drug Classes
-
2. Drug Action
- 2.1. Coccidiostatic
- 2.2. Coccidiocidal
-
3. Animal
-
3.1. Livestock Animals
- 3.1.1. Cattle
- 3.1.2. Poultry
- 3.1.3. Other Livestock Animals
-
3.2. Companion Animals
- 3.2.1. Dogs
- 3.2.2. Cats
- 3.2.3. Other Companion Animals
-
3.1. Livestock Animals
-
4. Distribution Channel
- 4.1. Veterinary Hospitals
- 4.2. Retail Pharmacy
- 4.3. Other Distribution Channels
Asia-Pacific Anticoccidial Drugs Industry Segmentation By Geography
-
1. Asia Pacific
- 1.1. China
- 1.2. Japan
- 1.3. South Korea
- 1.4. India
- 1.5. Australia
- 1.6. New Zealand
- 1.7. Indonesia
- 1.8. Malaysia
- 1.9. Singapore
- 1.10. Thailand
- 1.11. Vietnam
- 1.12. Philippines

Asia-Pacific Anticoccidial Drugs Industry REPORT HIGHLIGHTS
Aspects | Details |
---|---|
Study Period | 2019-2033 |
Base Year | 2024 |
Estimated Year | 2025 |
Forecast Period | 2025-2033 |
Historical Period | 2019-2024 |
Growth Rate | CAGR of 4.89% from 2019-2033 |
Segmentation |
|
Table of Contents
- 1. Introduction
- 1.1. Research Scope
- 1.2. Market Segmentation
- 1.3. Research Methodology
- 1.4. Definitions and Assumptions
- 2. Executive Summary
- 2.1. Introduction
- 3. Market Dynamics
- 3.1. Introduction
- 3.2. Market Drivers
- 3.2.1. Increasing Incidence of Coccidiosis; Advancements in Veterinary Healthcare
- 3.3. Market Restrains
- 3.3.1. Availability of Alternative Treatment Options in the Market
- 3.4. Market Trends
- 3.4.1. Poultry Segment is Expected to hold a Significant Share in the Anticoccidial Drugs Market Over The Forecast Period
- 4. Market Factor Analysis
- 4.1. Porters Five Forces
- 4.2. Supply/Value Chain
- 4.3. PESTEL analysis
- 4.4. Market Entropy
- 4.5. Patent/Trademark Analysis
- 5. Asia-Pacific Anticoccidial Drugs Industry Analysis, Insights and Forecast, 2019-2031
- 5.1. Market Analysis, Insights and Forecast - by Drug Class
- 5.1.1. Ionophore
- 5.1.2. Antibiotic
- 5.1.3. Sulphonamides
- 5.1.4. Chemical Derivative
- 5.1.5. Other Drug Classes
- 5.2. Market Analysis, Insights and Forecast - by Drug Action
- 5.2.1. Coccidiostatic
- 5.2.2. Coccidiocidal
- 5.3. Market Analysis, Insights and Forecast - by Animal
- 5.3.1. Livestock Animals
- 5.3.1.1. Cattle
- 5.3.1.2. Poultry
- 5.3.1.3. Other Livestock Animals
- 5.3.2. Companion Animals
- 5.3.2.1. Dogs
- 5.3.2.2. Cats
- 5.3.2.3. Other Companion Animals
- 5.3.1. Livestock Animals
- 5.4. Market Analysis, Insights and Forecast - by Distribution Channel
- 5.4.1. Veterinary Hospitals
- 5.4.2. Retail Pharmacy
- 5.4.3. Other Distribution Channels
- 5.5. Market Analysis, Insights and Forecast - by Region
- 5.5.1. Asia Pacific
- 5.1. Market Analysis, Insights and Forecast - by Drug Class
- 6. Competitive Analysis
- 6.1. Market Share Analysis 2024
- 6.2. Company Profiles
- 6.2.1 Ceva Animal Health Inc
- 6.2.1.1. Overview
- 6.2.1.2. Products
- 6.2.1.3. SWOT Analysis
- 6.2.1.4. Recent Developments
- 6.2.1.5. Financials (Based on Availability)
- 6.2.2 Elanco
- 6.2.2.1. Overview
- 6.2.2.2. Products
- 6.2.2.3. SWOT Analysis
- 6.2.2.4. Recent Developments
- 6.2.2.5. Financials (Based on Availability)
- 6.2.3 Boehringer Ingelheim International GmbH
- 6.2.3.1. Overview
- 6.2.3.2. Products
- 6.2.3.3. SWOT Analysis
- 6.2.3.4. Recent Developments
- 6.2.3.5. Financials (Based on Availability)
- 6.2.4 Novartis AG
- 6.2.4.1. Overview
- 6.2.4.2. Products
- 6.2.4.3. SWOT Analysis
- 6.2.4.4. Recent Developments
- 6.2.4.5. Financials (Based on Availability)
- 6.2.5 Zoetis Animal Healthcare
- 6.2.5.1. Overview
- 6.2.5.2. Products
- 6.2.5.3. SWOT Analysis
- 6.2.5.4. Recent Developments
- 6.2.5.5. Financials (Based on Availability)
- 6.2.6 Vetoquinol SA
- 6.2.6.1. Overview
- 6.2.6.2. Products
- 6.2.6.3. SWOT Analysis
- 6.2.6.4. Recent Developments
- 6.2.6.5. Financials (Based on Availability)
- 6.2.7 Impextraco NV
- 6.2.7.1. Overview
- 6.2.7.2. Products
- 6.2.7.3. SWOT Analysis
- 6.2.7.4. Recent Developments
- 6.2.7.5. Financials (Based on Availability)
- 6.2.8 MSD Animal Health
- 6.2.8.1. Overview
- 6.2.8.2. Products
- 6.2.8.3. SWOT Analysis
- 6.2.8.4. Recent Developments
- 6.2.8.5. Financials (Based on Availability)
- 6.2.9 Huvepharma
- 6.2.9.1. Overview
- 6.2.9.2. Products
- 6.2.9.3. SWOT Analysis
- 6.2.9.4. Recent Developments
- 6.2.9.5. Financials (Based on Availability)
- 6.2.10 Virbac
- 6.2.10.1. Overview
- 6.2.10.2. Products
- 6.2.10.3. SWOT Analysis
- 6.2.10.4. Recent Developments
- 6.2.10.5. Financials (Based on Availability)
- 6.2.11 Huvepharma
- 6.2.11.1. Overview
- 6.2.11.2. Products
- 6.2.11.3. SWOT Analysis
- 6.2.11.4. Recent Developments
- 6.2.11.5. Financials (Based on Availability)
- 6.2.1 Ceva Animal Health Inc
List of Figures
- Figure 1: Asia-Pacific Anticoccidial Drugs Industry Revenue Breakdown (Million, %) by Product 2024 & 2032
- Figure 2: Asia-Pacific Anticoccidial Drugs Industry Share (%) by Company 2024
List of Tables
- Table 1: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Region 2019 & 2032
- Table 2: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Region 2019 & 2032
- Table 3: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Drug Class 2019 & 2032
- Table 4: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Drug Class 2019 & 2032
- Table 5: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Drug Action 2019 & 2032
- Table 6: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Drug Action 2019 & 2032
- Table 7: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Animal 2019 & 2032
- Table 8: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Animal 2019 & 2032
- Table 9: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Distribution Channel 2019 & 2032
- Table 10: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Distribution Channel 2019 & 2032
- Table 11: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Region 2019 & 2032
- Table 12: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Region 2019 & 2032
- Table 13: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Country 2019 & 2032
- Table 14: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Country 2019 & 2032
- Table 15: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Drug Class 2019 & 2032
- Table 16: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Drug Class 2019 & 2032
- Table 17: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Drug Action 2019 & 2032
- Table 18: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Drug Action 2019 & 2032
- Table 19: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Animal 2019 & 2032
- Table 20: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Animal 2019 & 2032
- Table 21: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Distribution Channel 2019 & 2032
- Table 22: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Distribution Channel 2019 & 2032
- Table 23: Asia-Pacific Anticoccidial Drugs Industry Revenue Million Forecast, by Country 2019 & 2032
- Table 24: Asia-Pacific Anticoccidial Drugs Industry Volume Dosage Forecast, by Country 2019 & 2032
- Table 25: China Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 26: China Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 27: Japan Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 28: Japan Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 29: South Korea Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 30: South Korea Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 31: India Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 32: India Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 33: Australia Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 34: Australia Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 35: New Zealand Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 36: New Zealand Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 37: Indonesia Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 38: Indonesia Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 39: Malaysia Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 40: Malaysia Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 41: Singapore Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 42: Singapore Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 43: Thailand Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 44: Thailand Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 45: Vietnam Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 46: Vietnam Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
- Table 47: Philippines Asia-Pacific Anticoccidial Drugs Industry Revenue (Million) Forecast, by Application 2019 & 2032
- Table 48: Philippines Asia-Pacific Anticoccidial Drugs Industry Volume (Dosage) Forecast, by Application 2019 & 2032
Frequently Asked Questions
1. What is the projected Compound Annual Growth Rate (CAGR) of the Asia-Pacific Anticoccidial Drugs Industry?
The projected CAGR is approximately 4.89%.
2. Which companies are prominent players in the Asia-Pacific Anticoccidial Drugs Industry?
Key companies in the market include Ceva Animal Health Inc, Elanco, Boehringer Ingelheim International GmbH, Novartis AG, Zoetis Animal Healthcare, Vetoquinol SA, Impextraco NV, MSD Animal Health, Huvepharma, Virbac, Huvepharma.
3. What are the main segments of the Asia-Pacific Anticoccidial Drugs Industry?
The market segments include Drug Class, Drug Action, Animal, Distribution Channel.
4. Can you provide details about the market size?
The market size is estimated to be USD 390.12 Million as of 2022.
5. What are some drivers contributing to market growth?
Increasing Incidence of Coccidiosis; Advancements in Veterinary Healthcare.
6. What are the notable trends driving market growth?
Poultry Segment is Expected to hold a Significant Share in the Anticoccidial Drugs Market Over The Forecast Period.
7. Are there any restraints impacting market growth?
Availability of Alternative Treatment Options in the Market.
8. Can you provide examples of recent developments in the market?
In April 2022, to speed up the expansion of the veterinary laboratory in Japan, Ceva Santé Animale, a French-based animal health company, initiated a joint venture with Mitsui & Co., Ltd., one of the largest Japanese conglomerates to form Ceva Bussan Animal Health K.K. in Japan. This development was marked to address the food safety and animal disease control challenges in Japan.
9. What pricing options are available for accessing the report?
Pricing options include single-user, multi-user, and enterprise licenses priced at USD 4750, USD 5250, and USD 8750 respectively.
10. Is the market size provided in terms of value or volume?
The market size is provided in terms of value, measured in Million and volume, measured in Dosage.
11. Are there any specific market keywords associated with the report?
Yes, the market keyword associated with the report is "Asia-Pacific Anticoccidial Drugs Industry," which aids in identifying and referencing the specific market segment covered.
12. How do I determine which pricing option suits my needs best?
The pricing options vary based on user requirements and access needs. Individual users may opt for single-user licenses, while businesses requiring broader access may choose multi-user or enterprise licenses for cost-effective access to the report.
13. Are there any additional resources or data provided in the Asia-Pacific Anticoccidial Drugs Industry report?
While the report offers comprehensive insights, it's advisable to review the specific contents or supplementary materials provided to ascertain if additional resources or data are available.
14. How can I stay updated on further developments or reports in the Asia-Pacific Anticoccidial Drugs Industry?
To stay informed about further developments, trends, and reports in the Asia-Pacific Anticoccidial Drugs Industry, consider subscribing to industry newsletters, following relevant companies and organizations, or regularly checking reputable industry news sources and publications.
Methodology
Step 1 - Identification of Relevant Samples Size from Population Database



Step 2 - Approaches for Defining Global Market Size (Value, Volume* & Price*)

Note*: In applicable scenarios
Step 3 - Data Sources
Primary Research
- Web Analytics
- Survey Reports
- Research Institute
- Latest Research Reports
- Opinion Leaders
Secondary Research
- Annual Reports
- White Paper
- Latest Press Release
- Industry Association
- Paid Database
- Investor Presentations

Step 4 - Data Triangulation
Involves using different sources of information in order to increase the validity of a study
These sources are likely to be stakeholders in a program - participants, other researchers, program staff, other community members, and so on.
Then we put all data in single framework & apply various statistical tools to find out the dynamic on the market.
During the analysis stage, feedback from the stakeholder groups would be compared to determine areas of agreement as well as areas of divergence